CIMFS-32™ Cell Impedance and Field Potential Monitoring System

• The CELLAMES CIMFS-32™ (Cell Impedance and Field Potential Monitoring System) is developed for real-time and non-destructive monitoring of both cellular impedance and bioelectrical activity under various culture conditions.
• CIMFS-32™ integrates the complete features of the CIMS-32 and CFPS-32, bringing impedance and electrophysiological monitoring together in one system.
• It enables simultaneous assessment of morphological and electrophysiological changes in cells, providing comprehensive insights into cell behavior, function, and drug response.
• The CIMFS-32™ system integrates impedance-based cell analysis and local field potential (LFP) monitoring via MEA technology, making it a powerful platform for applications in cytotoxicity testing, cardiac safety evaluation, and immuno-oncology research.
• New Features: Contractility, Stimulation

• Real-time and non-destructive cell monitoring
• Visualization of cell adhesion, proliferation, and death
• CC50 and KT50 analysis from viability and cytolysis data
• Multi-frequency impedance measurement (1 kHz, 10 kHz, 100 kHz)
• Analysis of impedance magnitude, resistance, capacitance, and phase
• Raw and processed data export in Excel format(CSV, XLSX)
• Cell Proliferation, Cytotoxicity, Immuno-Oncology
• Customizable data view settings based on user preferences

• Real-time and Non-destructive Monitoring of cardiomyocyte and neuron activity
• MEA-based recording of bioelectrical signals
• Assessment of cardiomyocyte contraction strength via impedance
• Detection of drug-induced signal changes
• 12.5K Sample/s Sampling
• Measurement channel and time interval selection function
• Measurement of Beat Period, Spike Amplitude, and Field Potential Duration (FPD)
• Quantitative analysis of functional changes in excitable cells
• Detection of drug-induced signal changes
• User-friendly GUI and data analytics software

• Contractility
• Stimulation

• 32 Channel Measurement Station Compatible with Both CIMS-Plates/CFPS-Plates
• Laptop PC
• SW for Control, Data Acquisition, and Display
• Consumable CIMS-Plates/CFPS-Plates
• User-Friendly Access using USB Type-C Cable
• Removable Chamber for Staining and Microscopic
• Examination Without Cell Transfer

CIMFS-32™ Software

• Selectable impedance or field potential measurement modes in a 32-well format.
• User-friendly interface designed for intuitive data visualization and analysis.
• Impedance mode: Analyze magnitude, resistance, and capacitance at 100 kHz, 10 kHz, and 1 kHz.
• Field potential mode: High-speed waveform acquisition with real-time filtering.
• Automatic extraction of cardiomyocyte activity indicators: Beat Period, Spike Amplitude, and Field Potential Duration.
• Graphical outputs for evaluating cell viability, cytolysis, and electrophysiological behavior.
• Streamlined data control, export, and reporting tools for efficient workflow support.
• New Features: Contractility, Stimulation


Features Impedance
• Automated measurement of cell impedance in 32 well objects.
• The impedance magnitude, resistance, and capacitance can be checked specifically at the frequencies of 100 kHz, 10 kHz, and 1 kHz.
• Comprehensive graphs for assessing cell viability and cytolysis.
• Streamlined control and data output for efficient data analysis and reporting.

Cell Proliferation
• Impedance magnitude, resistance, and capacitance monitoring can provide valuable insight into cell proliferation and growth rates.

Cytotoxicity
• Makes it easy to monitor cell toxicity by generating viability or cytolysis graphs that show how cells respond to different drugs.
  These graphs provide valuable information about the impact of drugs on cells, allowing for useful toxicity assessment.




Field Potential
• Easily monitoring and analyze the field potential of cardiomyocyte.
• Accurate waveform display with fast sampling rate and filtering.
• Get important indicators of cardiomyocyte activity. Beat Period, Spike Amplitude, Field Potential Duration.
Measurement Parameters
• Beat Period, Spike Amplitude, and FPD(FPDcf)


Intuitive UI

Cardiotoxicity

Contractility
• Measurement of myocardial contractility

Stimulation
• Provides electrical stimulation and measures cardiomyocyte's electrophysical responses in real time.